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Analysis of RNA conformation in endogenously assembled RNPs by icSHAPE The majority of the mammalian genome is transcribed into non-coding RNAs, many of which co-evolve with RNA-binding proteins (RBPs) to function as biochemically defined and tractable ribonucleoproteins (RNPs). Here, we applied icSHAPE, a robust and versatile RNA structural probing pipeline, to endogenous RNPs purified from ...
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For collecting and storing clinical research data, REDCap can safely store private and confidential health data in accordance with HIPAA and FISMA regulations.
https://sites.temple.edu/ticlj/files/2017/02/30.1.Scharre-TICLJ.pdf
Paul Scharre* Much of the debate on autonomous weapons presumes a choice between human versus autonomous decision-making over targeting and engagement decisions. In fact, in many situations, human-machine teaming in engagement decisions will not only be possible but preferable. Hybrid human-machine cognitive architectures will be able to leverage the precision and reliability of automation ...
https://dabi.temple.edu/external/zoran/papers/Dunker_TPT.pdf
For ordered protein, the ensemble members all have the same time-averaged canonical set of Ramachandran angles along their backbones. For intrinsically disordered protein, the ensemble members have different (and typically dynamic) Ramachandran angles. Such disorder has been characterized by a variety of methods including x-ray crystallography, NMR spectroscopy, CD spectroscopy, and protease ...
https://sites.temple.edu/newcombe/files/2013/06/Newcombe_et_al-2015-Wiley_Interdisciplinary_Reviews-_Cognitive_Science.pdf
(e.g., radial distance and angle) rather than just one, children cannot coordinate categorical and metric coding until about 9 years of age.22 Third, the spatial categories used become smaller with age, and hence more informative; adjustment by a smaller category draws estimates to a prototype value closer to the actual location.
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